BACKGROUND: The Escherichia coli chaperonin GroEL subunit consists of three domains linked via two hinge regions, and each domain is responsible for a specific role in the functional mechanism.Here, we have used circular permutation to study the structural and functional characteristics of the GroEL subunit.METHODOLOGY/PRINCIPAL FINDINGS: Three sol
Abstract Background Pragmatic randomized controlled trials (RCTs) are designed to evaluate the effectiveness of interventions in real-world clinical conditions.However, these studies raise ethical One Eared Western Bridles issues for researchers and regulators.Our objective is to identify a list of key ethical issues in pragmatic RCTs and highlight
Penentuan rute armada merupakan salah satu permasalahan optimisasi kombinatorik yang memiliki pengaruh pada distribusi barang.Pengiriman barang cepat Cookie Cutter busuk (perishable good) seperti produk darah, dengan karakteristik jarak tempuh yang pendek memungkinkan untuk dilakukan dengan satu kendaraan.Terdapat kendala time windows pada pelangga
COVID-19 is bringing hardship and tragedy.Health workers are having to take appalling risks; loved ones are being ADRENAL lost; lockdown is causing great distress.And, as always in testing times, the disadvantaged are being hit worst.As we emerge from the shadows, the call from the vested interests, from the systems Cookie Cutter current winners, w